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Dysregulation of follicle development in a mouse model of premature ovarian insufficiency.

Abstract:

Premature ovarian insufficiency (POI) occurs in 1% of women of reproductive age. The ovarian manifestation ranges from the presence of a variable population of follicles (follicular) to the absence of follicles (afollicular), and in the majority of cases the cause is unknown. A transgenic mouse model of follicular POI, the Double Mutant (DM), arises from oocyte-specific deletion of Mgat1 and C1galt1 required for the generation of O- and N-glycans. DM females are sub-fertile at 6 weeks, infert...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1530/REP-16-0091

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics & Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics & Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics & Gynaecology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Funding agency for:
Sheikh, S
Publisher:
BioScientifica Publisher's website
Journal:
Reproduction Journal website
Volume:
152
Issue:
5
Pages:
591-601
Publication date:
2016-08-31
Acceptance date:
2016-08-31
DOI:
EISSN:
1741-7899
ISSN:
1470-1626
Pubs id:
pubs:641792
URN:
uri:d96f0122-f22d-4b69-ae31-a1d6f0c67efe
UUID:
uuid:d96f0122-f22d-4b69-ae31-a1d6f0c67efe
Local pid:
pubs:641792
Language:
English
Keywords:

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