Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.

Journal article

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is the most common cause of rapidly progressive glomerulonephritis and immune-mediated pulmonary renal syndrome. Now that the acute manifestations of the disease generally can be controlled with immunosuppressive drugs, ANCA-associated vasculitis has become a chronic and relapsing inflammatory disorder. The need to develop safer and more effective treatment has led to great interest in the mediators of chronic inflammation. The...

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Authors: Feldmann, M; Pusey, C

• Publication status: Published
• Journal: Journal of the American Society of Nephrology : JASN
• Volume: 17
• Issue: 5
• Pages: 1243-1252
• Publication date: 2006-05-01
• DOI: 10.1681/asn.2005121359
• EISSN: 1533-3450
• ISSN: 1046-6673
• Language: English
• Keywords: Humans; Animals; Antibodies, Monoclonal; Cytoplasmic Granules; Antibodies, Antineutrophil Cytoplasmic; Vasculitis; Inflammation; Glomerulonephritis; Tumor Necrosis Factor-alpha; Cytoplasm