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Journal article

Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells.

Abstract:

The question of whether enhanced memory T cell responses are simply due to an increased frequency of specific cells or also to an improved response at the single cell level is widely debated. In this study, we analyzed T cell receptor (TCR) transgenic memory T cells and bona fide memory T cells isolated from virally infected normal mice using the tetramer technology. We found that memory T cells are qualitatively different from naive T cells due to a developmentally regulated rearrangement of...

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Publication status:
Published

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Publisher copy:
10.1084/jem.189.10.1521

Authors


Bachmann, MF More by this author
Gallimore, A More by this author
Linkert, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Lanzavecchia, A More by this author
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Journal:
The Journal of experimental medicine
Volume:
189
Issue:
10
Pages:
1521-1530
Publication date:
1999-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:d924b5ab-5d11-40bd-bd80-497696a84495
Source identifiers:
31484
Local pid:
pubs:31484

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