Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells.

Journal article

The question of whether enhanced memory T cell responses are simply due to an increased frequency of specific cells or also to an improved response at the single cell level is widely debated. In this study, we analyzed T cell receptor (TCR) transgenic memory T cells and bona fide memory T cells isolated from virally infected normal mice using the tetramer technology. We found that memory T cells are qualitatively different from naive T cells due to a developmentally regulated rearrangement of...

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Authors: Bachmann, M; Gallimore, A; Linkert, S; Cerundolo, V; Lanzavecchia, A

• Publication status: Published
• Journal: Journal of experimental medicine
• Volume: 189
• Issue: 10
• Pages: 1521-1530
• Publication date: 1999-05-01
• DOI: 10.1084/jem.189.10.1521
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Immunologic Memory; Antigens, CD28; Spleen; Microscopy, Fluorescence; Calcium; Flow Cytometry; Receptors, Antigen, T-Cell; Acetyltransferases; Mice; Lymphocyte Activation; Proteins; Lymphocytic choriomeningitis virus; Mice, Transgenic; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Signal Transduction; Cells, Cultured; Animals; CD8-Positive T-Lymphocytes