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Genetic hitchhiking in spatially extended populations

Abstract:

When a mutation with selective advantage s spreads through a panmictic population, it may cause two lineages at a linked locus to coalesce; the probability of coalescence is exp ( - 2. r T) , where T ~ log (2. N s) / s is the time to fixation, N is the number of haploid individuals, and r is the recombination rate. Population structure delays fixation, and so weakens the effect of a selective sweep. However, favourable alleles spread through a spatially continuous population behind a narrow w...

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Publisher copy:
10.1016/j.tpb.2012.12.001

Authors


Barton, NH More by this author
Etheridge, AM More by this author
Kelleher, J More by this author
Journal:
Theoretical Population Biology
Volume:
87
Issue:
1
Pages:
75-89
Publication date:
2013-08-05
DOI:
EISSN:
1096-0325
ISSN:
0040-5809
URN:
uuid:d919dd3b-553d-4729-9470-9dff355e705b
Source identifiers:
417339
Local pid:
pubs:417339

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