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Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.

Abstract:

PURPOSE: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis and is an important target in the development of anticancer drugs. However, VEGF receptor (VEGFR) expression in human cancers, particularly the relative expression of VEGFR-2 and VEGFR-3 in tumor vasculature versus tumor cells, is poorly defined. EXPERIMENTAL DESIGN: VEGFR-2- and VEGFR-3-specific antibodies were identified and used in the immunohistochemical analysis of human primary cancers and normal ...

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Publication status:
Published

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Authors


Ratcliffe, K More by this author
Jenkins, M More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
16
Issue:
14
Pages:
3548-3561
Publication date:
2010-07-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:d90afaa9-ccaa-4bc9-84b9-af05b58cb5e5
Source identifiers:
315720
Local pid:
pubs:315720

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