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Cardiosphere-derived stem cell culture, characterisation and labelling for in vivo testing in the infarcted heart

Abstract:

Cardiac stem cells (CSCs), isolated from heart tissue explants and expanded via the formation of cardiospheres (Csp), are a promising candidate for cell therapy to prevent heart failure following myocardial infarction. To allow early administration to patients, isolation and expansion of CSCs must be performed in the shortest time possible. Hence, this project aimed to optimize culture conditions and characterize the cardiac explant-derived cells (EDCs), Csp and Csp-derived cells (CDCs) produ...

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Institution:
University of Oxford
Research group:
Cardiac Metabolism Research Group
Oxford college:
Oriel College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d902b4f4-6e32-45dd-9767-8e0a17967393
Local pid:
ora:5443

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