Journal article
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse
- Abstract:
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Background
Mutations of the common cytokine receptor gamma chain (γc) cause Severe Combined Immunodeficiency characterized by absent T and NK cell development. Although stem cell therapy restores these lineages, residual immune defects are observed that may result from selective persistence of γc-deficiency in myeloid lineages. However, little is known about the contribution of myeloid-expressed γc to protective immune responses. Here we examine the importance of γc for myeloid d...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, zip, 16.9MB, Terms of use)
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(Preview, Version of record, pdf, 6.5MB, Terms of use)
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- Publisher copy:
- 10.12688/wellcomeopenres.14493.2
Authors
Funding
Bibliographic Details
- Publisher:
- Wellcome Trust
- Journal:
- Wellcome Open Research More from this journal
- Volume:
- 3
- Pages:
- 84
- Publication date:
- 2017-07-17
- Acceptance date:
- 2018-07-01
- DOI:
- EISSN:
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2398-502X
- ISSN:
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0022-1767
Item Description
- Keywords:
- Pubs id:
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pubs:871953
- UUID:
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uuid:d8f35139-9617-4c91-bf1f-bacb2f4f4722
- Local pid:
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pubs:871953
- Source identifiers:
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871953
- Deposit date:
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2018-10-14
Terms of use
- Copyright holder:
- Beilin et al
- Copyright date:
- 2017
- Notes:
- © 2018 Beilin C et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.*
- Licence:
- CC Attribution (CC BY)
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