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Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse

Abstract:

Background

Mutations of the common cytokine receptor gamma chain (γc) cause Severe Combined Immunodeficiency characterized by absent T and NK cell development. Although stem cell therapy restores these lineages, residual immune defects are observed that may result from selective persistence of γc-deficiency in myeloid lineages. However, little is known about the contribution of myeloid-expressed γc to protective immune responses. Here we examine the importance of γc for myeloid d...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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ORCID:
0000-0003-1574-3256
Choudhuri, K More by this author
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ORCID:
0000-0002-1465-9178
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ORCID:
0000-0003-0784-5703
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European Union More from this funder
Cancer Research Institute More from this funder
Primary Immunodeficiency Association More from this funder
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Publisher:
Wellcome Trust Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
3
Pages:
84
Publication date:
2017-07-17
Acceptance date:
2018-07-01
DOI:
EISSN:
2398-502X
ISSN:
0022-1767
Pubs id:
pubs:871953
URN:
uri:d8f35139-9617-4c91-bf1f-bacb2f4f4722
UUID:
uuid:d8f35139-9617-4c91-bf1f-bacb2f4f4722
Local pid:
pubs:871953

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