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Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies.

Abstract:

The mammalian skull vault is constructed principally from five bones: the paired frontals and parietals, and the unpaired interparietal. These bones abut at sutures, where most growth of the skull vault takes place. Sutural growth involves maintenance of a population of proliferating osteoprogenitor cells which differentiate into bone matrix-secreting osteoblasts. Sustained function of the sutures as growth centres is essential for continuous expansion of the skull vault to accommodate the gr...

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Publication status:
Published

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Authors


Morriss-Kay, GM More by this author
Wilkie, AO More by this author
Journal:
Journal of anatomy
Volume:
207
Issue:
5
Pages:
637-653
Publication date:
2005-11-05
DOI:
EISSN:
1469-7580
ISSN:
0021-8782
URN:
uuid:d8f0ef88-d340-47af-abfc-014c9342ffe3
Source identifiers:
119998
Local pid:
pubs:119998

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