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Synthesis of [I-123]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one, a potential dopamine D4 ligand for SPECT studies

Abstract:

Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for the positive symptoms of the disorder, more exactly hyperactivity of the dopamine D2-like receptors. One of these receptors is the D4 receptor which is thought to be involved in the motor side-effects caused a...

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Publication status:
Published

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Publisher copy:
10.1002/jlcr.902

Authors


Staelens, L More by this author
Oltenfreiter, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Blanckaert, P More by this author
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Journal:
JOURNAL OF LABELLED COMPOUNDS and RADIOPHARMACEUTICALS
Volume:
48
Issue:
2
Pages:
101-108
Publication date:
2005-02-05
DOI:
EISSN:
1099-1344
ISSN:
0362-4803
URN:
uuid:d8e7d8e6-7fe9-438e-928f-e971faf5305e
Source identifiers:
280296
Local pid:
pubs:280296
Language:
English
Keywords:

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