Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand

Journal article

Background. Previous efficacy trials of SPf66 malaria vaccine have produced conflicting results in different populations. We report a randomised double-blind trial of the SPf66 vaccine conducted in Karen children aged 2-15 living in a malarious region of northwestern Thailand. Recombinant hepatitis B vaccine was used as a comparator. Methods. The study had a power of 90% to detect an efficacy of 30%, defined as a reduction in the incidence of first cases of symptomatic falciparum malaria afte...

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Authors: Nosten, F; Luxemburger, C; Kyle, D; Ballou, W; Wittes, J

• Publication status: Published
• Journal: LANCET
• Volume: 348
• Issue: 9029
• Pages: 701-707
• Publication date: 1996-09-14
• DOI: 10.1016/S0140-6736(96)04465-0
• ISSN: 0140-6736