Journal article
Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.
- Abstract:
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BACKGROUND: XPC is involved in the nucleotide excision repair of DNA damaged by carcinogens known to cause bladder cancer. Individuals homozygous for the variant allele of XPC c.1496C > T (p.Ala499Val) were shown in a large pooled analysis to have an increased bladder cancer risk, and we found two 3'UTR variants, *611T > A and c.*618A > G, to be in strong linkage disequilibrium with c.1496T. Here we determined if these two 3'UTR variants can affect mRNA stability and assessed the im...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 841.8KB, Terms of use)
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- Publisher copy:
- 10.1186/1471-2350-12-84
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Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- BMC medical genetics More from this journal
- Volume:
- 12
- Issue:
- 1
- Pages:
- 84
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1471-2350
- ISSN:
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1471-2350
Item Description
- Language:
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English
- Keywords:
- UUID:
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uuid:d8d33ec8-a503-408a-95e6-a7d1909e8192
- Local pid:
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pubs:154239
- Source identifiers:
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154239
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Qiao et al
- Copyright date:
- 2011
- Notes:
- © 2011 Qiao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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