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Dehydroepiandrosterone (DHEA) reduces neuronal injury in a rat model of global cerebral ischemia.

Abstract:

INTRODUCTION: Many studies report an inverse correlation between levels of DHEA and neurological diseases. Exogenous DHEA protects hippocampal neurons against excitatory amino acid induced neurotoxicity. The purpose of this experiment is to evaluate the effect of DHEA in an animal model of transient but severe forebrain ischemia. METHODS: At thirteen days prior to induction of ischemia, male Wistar rats were implanted with various doses of DHEA-placebo, 25 mg, 50 mg or 100 mg. Forebrain ische...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
Journal:
Brain research
Volume:
888
Issue:
2
Pages:
263-266
Publication date:
2001-01-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:d8ca99c7-af64-4a82-a7d5-9b8ad4e598ac
Source identifiers:
79039
Local pid:
pubs:79039

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