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Syndecans promote mycobacterial internalization by lung epithelial cells

Abstract:

Pulmonary tuberculosis (TB) is an airborne disease caused by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb). Alveolar epithelial cells and macrophages are the first point of contact for Mtb in the respiratory tract. However, the mechanisms of mycobacterial attachment to, and internalization by, nonprofessional phagocytes, such as epithelial cells, remain incompletely understood. We identified syndecan 4 (Sdc4) as mycobacterial attachment receptor on alveolar epithelial ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/cmi.12627

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Cellular Microbiology Journal website
Volume:
18
Issue:
12
Pages:
1846-1856
Publication date:
2016-06-09
Acceptance date:
2016-06-05
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Pubs id:
pubs:939834
URN:
uri:d8c63b6a-bed2-4370-b820-7626dca6742c
UUID:
uuid:d8c63b6a-bed2-4370-b820-7626dca6742c
Local pid:
pubs:939834

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