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Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition

Abstract:

Aims/hypothesis Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional studies have focused on the latter, given limitations regarding access to human fetal islet tissue. Capitalising upon advances in in vitro differentiation, we...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00125-018-4612-4

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Honoré, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM; NDM
ORCID:
0000-0003-1205-1844
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Oxford college:
Green Templeton College
ORCID:
0000-0002-4393-0510
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Innovative Medicines Initiative Joint Undertaking More from this funder
Seventh Framework Programme More from this funder
More from this funder
Grant:
098381
106130
090532
203141
95101
200837
H5R00430
European Federation of Pharmaceutical Industries and Associations More from this funder
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Publisher:
Springer Publisher's website
Journal:
Diabetologia Journal website
Volume:
61
Issue:
7
Pages:
1614–1622
Publication date:
2018-04-19
Acceptance date:
2018-03-12
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Pubs id:
pubs:844671
URN:
uri:d8ab41a5-3eeb-4a7c-b141-15410be97e4f
UUID:
uuid:d8ab41a5-3eeb-4a7c-b141-15410be97e4f
Local pid:
pubs:844671

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