The role of catecholamines in the production of ischaemia-induced ventricular arrhythmias in the rat in vivo and in vitro.

Journal article

The role of catecholamines in the production of ischaemia-induced ventricular arrhythmias in vivo and in vitro was studied using coronary artery ligation in the rat. Increases in plasma catecholamine concentrations during coronary artery ligation in pentobarbitone-anaesthetized animals were prevented by either acute adrenalectomy or chronic adrenal demedullation, but these procedures did not protect against the occurrence of ventricular arrhythmias. Thus plasma catecholamines were not obligat...

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Authors: Daugherty, A; Frayn, K; Redfern, W; Woodward, B

• Publication status: Published
• Journal: British journal of pharmacology
• Volume: 87
• Issue: 1
• Pages: 265-277
• Publication date: 1986-01-01
• DOI: 10.1111/j.1476-5381.1986.tb10180.x
• EISSN: 1476-5381
• ISSN: 0007-1188
• Language: English
• Keywords: Lidocaine; Desipramine; Male; Tritium; Catecholamines; Quinidine; Adrenergic alpha-Antagonists; Rats, Inbred Strains; Norepinephrine; Myocardium; Adrenal Medulla; Normetanephrine; Arrhythmias, Cardiac; Animals; Reserpine; Rats; Sympathectomy, Chemical; Adrenergic beta-Antagonists; Anesthesia; Adrenalectomy; Coronary Disease