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Polar redistribution of the sialoglycoprotein CD43: implications for T cell function.

Abstract:

Contact between T cells and APCs results in the orchestrated segregation of molecules at the cell-cell interface and formation of a specialized structure termed the immunological synapse. This model predicts the topological seclusion of large molecules such as CD43 from the site of closest contact between the T cell and APC, allowing for the close apposition of cell membranes and effective TCR engagement. Similarly, during T cell migration segregation of CD43 to the uropod is thought to aid i...

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Publisher copy:
10.4049/jimmunol.168.8.3740

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
168
Issue:
8
Pages:
3740-3746
Publication date:
2002-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:d88f2ee8-c968-416b-b7f6-c7f4bca0751a
Source identifiers:
482654
Local pid:
pubs:482654

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