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Polar redistribution of the sialoglycoprotein CD43: implications for T cell function.

Abstract:

Contact between T cells and APCs results in the orchestrated segregation of molecules at the cell-cell interface and formation of a specialized structure termed the immunological synapse. This model predicts the topological seclusion of large molecules such as CD43 from the site of closest contact between the T cell and APC, allowing for the close apposition of cell membranes and effective TCR engagement. Similarly, during T cell migration segregation of CD43 to the uropod is thought to aid i...

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Publisher copy:
10.4049/jimmunol.168.8.3740

Authors


Savage, ND More by this author
Kimzey, SL More by this author
Bromley, SK More by this author
Johnson, KG More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
168
Issue:
8
Pages:
3740-3746
Publication date:
2002-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:d88f2ee8-c968-416b-b7f6-c7f4bca0751a
Source identifiers:
482654
Local pid:
pubs:482654

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