Thesis icon

Thesis

On genetic variants underlying common disease

Abstract:

Genome-wide association studies (GWAS) exploit the correlation in ge- netic diversity along chromosomes in order to detect effects on disease risk without having to type causal loci directly. The inevitable downside of this approach is that, when the correlation between the marker and the causal variant is imperfect, the risk associated with carrying the predisposing allele is diluted and its effect is underestimated. This thesis explores four different facets of this risk dilution: (1) es...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Research group:
Donnelly Group
Oxford college:
St John's College
Department:
Mathematical,Physical & Life Sciences Division - Statistics

Contributors

Role:
Supervisor
More from this funder
Funding agency for:
Eliana Hechter
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:d883f20e-7dad-4216-8851-b006993832fd
Local pid:
ora:6281

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP