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Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload.

Abstract:

Endothelial nitric oxide synthase (eNOS) was assumed to be the only source of nitric oxide (NO) involved in the regulation of human coronary blood flow (CBF). However, our recent first-in-human study using the neuronal NOS (nNOS)-selective inhibitor S-methyl-L-thiocitrulline (SMTC) showed that nNOS-derived NO also plays a role. In this study, we investigated the relative contribution of nNOS and eNOS to the CBF response to a pacing-induced increase in cardiac workload. Incremental right atria...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00927.2012

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
304
Issue:
9
Pages:
H1277-H1282
Publication date:
2013-05-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:d8831dac-caff-47b9-a900-f0a3edc27d94
Source identifiers:
387797
Local pid:
pubs:387797

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