Regulation of extracellular calcium sensing in rat osteoclasts by femtomolar calcitonin concentrations.

Journal article

Certain eukaryotic cells can sense changes in their extracellular Ca2+ concentration through molecular structures termed Ca(2+)-sensing receptors (CaRs). We have shown recently that in the bone-resorbing osteoclast, a unique cell surface-expressed ryanodine receptor (RyR), functions as the CaR. The present study demonstrates that the sensitivity of this receptor is modulated by physiological femtomolar concentrations of the bone-conserving hormone, calcitonin. Calcitonin was found to inhibit ...

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Authors: Zaidi, M; Shankar, V; Adebanjo, O; Lai, F; Pazianas, M

• Journal: American journal of physiology
• Volume: 271
• Issue: 3 Pt 2
• Pages: F637-F644
• Publication date: 1996-09-01
• ISSN: 0002-9513
• Language: English
• Keywords: Osteoclasts; Rats; Cyclic AMP; Calcium; Osmolar Concentration; Calcium Channel Blockers; Extracellular Space; Cytosol; Calcitonin; Calcium-Binding Proteins; Nickel; Animals; Rats, Wistar