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Journal article

Lack of truncated IFITM3 transcripts in cells homozygous for the rs12252-C variant that is associated with severe influenza infection

Abstract:

Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/infdis/jix512

Authors


Makvandi-Nejad, S More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
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National Natural Science Foundation of China More from this funder
Beijing Natural Science Foundation More from this funder
National S and T Major Project for Infectious Diseases Control More from this funder
Beijing Municipal Administration of Hospitals More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
217
Issue:
2
Pages:
257–262
Publication date:
2017-11-30
Acceptance date:
2017-09-26
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pubs id:
pubs:809649
URN:
uri:d878e4de-eca4-4c67-a1ed-64af9624a84f
UUID:
uuid:d878e4de-eca4-4c67-a1ed-64af9624a84f
Local pid:
pubs:809649
Language:
English
Keywords:

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