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Regulatory mechanisms in graft-versus-host responses.

Abstract:

Graft-versus-host disease (GVHD) is induced by donor T cells cotransplanted with the stem cell graft. The main risk factors for the development of GVHD are the degree of HLA disparity between donor and recipient and the precursor frequency and intensity of T cell responses against major or minor histocompatibility antigens. However, allogeneic T cell responses do not occur in a static and sterile environment, but are modulated by the inflammatory milieu in lymphoid and GVHD target tissues tha...

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Publication status:
Published

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Publisher copy:
10.1016/j.bbmt.2008.10.013

Authors


Edinger, M More by this author
Chakraverty, R More by this author
Volume:
15
Issue:
1 Suppl
Pages:
2-6
Publication date:
2009-01-05
DOI:
EISSN:
1523-6536
ISSN:
1083-8791
URN:
uuid:d8775878-ce57-4058-b7f0-959a0de1f00a
Source identifiers:
29451
Local pid:
pubs:29451

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