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Helix dynamics in a membrane transport protein: comparative simulations of the glycerol-3-phosphate transporter and its constituent helices.

Abstract:

The glycerol-3-phosphate transporter (GlpT) is a member of the major facilitator superfamily (MFS). GlpT is an organic phosphate/inorganic phosphate antiporter. It shares a similar fold with other MFS transporters (e.g. LacY and EmrD) consisting of 12 transmembrane (TM) helices which form two domains (each of six TM helices) surrounding a central ligand-binding cavity. The TM helices (especially the cavity-lining helices) contain a large number of proline and glycine residues, which may aid i...

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Publication status:
Published

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Publisher copy:
10.1080/09687680802549113

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Journal:
Molecular membrane biology
Volume:
25
Issue:
6-7
Pages:
571-583
Publication date:
2008-09-05
DOI:
EISSN:
1464-5203
ISSN:
0968-7688
URN:
uuid:d86b4518-7075-458c-86cc-d876f714b5c6
Source identifiers:
100661
Local pid:
pubs:100661

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