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Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

Abstract:

OBJECTIVE: Lipotoxicity and ectopic fat deposition reduce insulin signaling. It is not clear whether excess fat deposition in nonadipose tissue arises from excessive fatty acid delivery from adipose tissue or from impaired adipose tissue storage of ingested fat. RESEARCH DESIGN AND METHODS: To investigate this we used a whole-body integrative physiological approach with multiple and simultaneous stable-isotope fatty acid tracers to assess delivery and transport of endogenous and exogenous fa...

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Publication status:
Published

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Publisher copy:
10.2337/db10-0867

Authors


McQuaid, SE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Neville, MJ More by this author
Dennis, AL More by this author
Cheeseman, J More by this author
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Journal:
Diabetes
Volume:
60
Issue:
1
Pages:
47-55
Publication date:
2011-01-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:d869b675-5b0a-4d4f-bb09-3cf9dff266c1
Source identifiers:
90301
Local pid:
pubs:90301

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