- Abstract:
-
OBJECTIVE: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associated with pathogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4). The presence of neutrophils is a characteristic feature in NMO lesions in humans. Neutrophils are not generally found in multiple sclerosis lesions. We evaluated the role of neutrophils in a mouse NMO model. METHODS: NMO lesions were produced in mice by intracerebral injection of ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/ana.22686
-
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- Journal:
- Annals of neurology
- Volume:
- 71
- Issue:
- 3
- Pages:
- 323-333
- Publication date:
- 2012-03-05
- DOI:
- EISSN:
-
1531-8249
- ISSN:
-
0364-5134
- URN:
-
uuid:d866d59d-0f4a-47c2-85d9-1eec2927cb6a
- Source identifiers:
-
317002
- Local pid:
- pubs:317002
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
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