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Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.

Abstract:

OBJECTIVE: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associated with pathogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4). The presence of neutrophils is a characteristic feature in NMO lesions in humans. Neutrophils are not generally found in multiple sclerosis lesions. We evaluated the role of neutrophils in a mouse NMO model. METHODS: NMO lesions were produced in mice by intracerebral injection of ...

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Publication status:
Published

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Publisher copy:
10.1002/ana.22686

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Annals of neurology
Volume:
71
Issue:
3
Pages:
323-333
Publication date:
2012-03-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:d866d59d-0f4a-47c2-85d9-1eec2927cb6a
Source identifiers:
317002
Local pid:
pubs:317002

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