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Thesis

Hydrogen Sulfide (H2S) as a regulator of myocardial redox state and the redox-sensitive regulation of cystathionine γ-lyase (CSE)

Abstract:

In advanced stages, cardiac disease causes millions of deaths each year. Superoxide anions (O2.-) and their derivative peroxynitrite (ONOO-) contribute to cardiac disease pathogenesis, yet strategies to reduces these reactive oxygen species through antioxidants in large scale clinical trials have largely been unsuccessful. Better understanding of pathways regulating enzymatic sources of O2.- like NADPH oxidases, uncoupled nitric oxide ...

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Department:
Radcliffe Department of Medicine; Division of Cardiovascular Medicine; Balliol College

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Department:
Radcliffe Department of Medicine; Division of Cardiovascular Medicine
Role:
Supervisor
Department:
Radcliffe Department of Medicine; Division of Cardiovascular Medicine
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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