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Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Abstract:

Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been reported, the full spectrum of MeCP2 phosphorylation together with the in vivo function of such modifications are yet to be revealed. Here, we report the identification of several MeCP2 phosphorylati...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0811648106

Authors


Sherman, NE More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
12
Pages:
4882-4887
Publication date:
2009-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d85f31a0-4213-42a7-b7e1-bff1c8b7ba2d
Source identifiers:
99913
Local pid:
pubs:99913

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