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Monitoring the disassembly of virus-like particles by (19)F-NMR

Abstract:

Virus-like particles (VLPs) are stable protein cages derived from virus coats. They have been used extensively as biomolecular platforms, e.g., nanocarriers or vaccines, but a convenient in situ technique is lacking for tracking functional status. Here, we present a simple way to monitor disassembly of (19)F-labeled VLPs derived from bacteriophage Qβ by (19)F NMR. Analysis of resonances, under a range of conditions, allowed determination not only of the particle as fully assembled but also as...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/jacs.6b11040

Authors


Robinson, MDM More by this author
Ajabali, AAA More by this author
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
139
Issue:
15
Pages:
5277–5280
Publication date:
2017-04-07
Acceptance date:
2017-03-28
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Pubs id:
pubs:688721
URN:
uri:d857d31e-9190-4f6d-a11c-f663ea488cfc
UUID:
uuid:d857d31e-9190-4f6d-a11c-f663ea488cfc
Local pid:
pubs:688721
Language:
English
Keywords:

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