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Impact of biologic therapies on need for hip and knee replacement among rheumatoid arthritis and non-rheumatoid arthritis patients in Ontario, Canada: An interrupted time-series analysis

Abstract:

Rates of orthopaedic surgery among rheumatoid arthritis (RA) patients have been decreasing in several developed countries. One explanatory factor could be the introduction of biologic therapies. Whilst we recently tested this hypothesis using UK data, analyses that account for concurrent trends in non-RA patients is lacking. Our aim here was to estimate the impact of approval of tumour necrosis factor inhibitor therapy (TNFi) for RA on the need for total hip (THR) and total knee replacement (...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1093/rheumatology/kex062.208

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Edwards, CJ More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
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Publisher:
Oxford University Press Publisher's website
Publication date:
2017-04-21
Acceptance date:
2016-12-16
DOI:
ISSN:
1462-0324
Pubs id:
pubs:727868
URN:
uri:d8529ff6-59e1-4b88-bb06-4115f54ff0c2
UUID:
uuid:d8529ff6-59e1-4b88-bb06-4115f54ff0c2
Local pid:
pubs:727868

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