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The m74 gene product of murine cytomegalovirus (MCMV) is a functional homolog of human CMV gO and determines the entry pathway of MCMV.

Abstract:

The glycoprotein gO (UL74) of human cytomegalovirus (HCMV) forms a complex with gH/gL. Virus mutants with a deletion of gO show a defect in secondary envelopment with the consequence that virus spread is restricted to a cell-associated pathway. Here we report that the positional homolog of HCMV gO, m74 of mouse CMV (MCMV), codes for a glycosylated protein which also forms a complex with gH (M75). m74 knockout mutants of MCMV show the same spread phenotype as gO knockout mutants of HCMV, namel...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02441-09

Authors


Scrivano, L More by this author
Esterlechner, J More by this author
Mühlbach, H More by this author
Ettischer, N More by this author
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Journal:
Journal of virology
Volume:
84
Issue:
9
Pages:
4469-4480
Publication date:
2010-05-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:d852313f-0c0a-4366-99e3-a02c3a1a4a7f
Source identifiers:
104036
Local pid:
pubs:104036

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