Significant linkage to migraine with aura on chromosome 11q24.

Journal article

Migraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare Mendelian form of MA, can be caused by mutations in the calcium channel gene, CACNA1A or in the ATP1A2 gene, a Na+/K+ pump. Susceptibility genes for the more prevalent forms of migraine have yet to be identified despite several reports of linkage including loci on 4q24, 1q31, 19p13 and Xq24-28. We have undertaken a genome-wide screen of 43 Canadian famil...

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Authors: Cader, Z; Noble-Topham, S; Dyment, D; Cherny, S; Brown, J

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 12
• Issue: 19
• Pages: 2511-2517
• Publication date: 2003-10-01
• DOI: 10.1093/hmg/ddg252
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Pedigree; Humans; Genes, Dominant; Genetic Predisposition to Disease; Genetic Linkage; Sex Ratio; Genetic Heterogeneity; Lod Score; Chromosome Mapping; Trinucleotide Repeats; Migraine with Aura; Genome, Human; Statistics as Topic; Microsatellite Repeats; Genetic Testing; Chromosomes, Human, Pair 11; Heterozygote