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Journal article

Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.

Abstract:

Molecular classification of colorectal cancer (CRC) is currently based on microsatellite instability (MSI), KRAS or BRAF mutation and, occasionally, chromosomal instability (CIN). Whilst useful, these categories may not fully represent the underlying molecular subgroups. We screened 906 stage II/III CRCs from the VICTOR clinical trial for somatic mutations. Multivariate analyses (logistic regression, clustering, Bayesian networks) identified the primary molecular associations. Positive associ...

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Publication status:
Published

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Publisher copy:
10.1002/path.4139

Authors


Domingo, E More by this author
Ramamoorthy, R More by this author
Rosmarin, D More by this author
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Journal:
The Journal of pathology
Volume:
229
Issue:
3
Pages:
441-448
Publication date:
2013-02-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:d84215ff-b21c-426a-9888-bbb8f859012e
Source identifiers:
363808
Local pid:
pubs:363808

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