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Similar nociceptive afferents mediate psychophysical and electrophysiological responses to heat stimulation of glabrous and hairy skin in humans

Abstract:

The ability to perceive and withdraw rapidly from noxious environmental stimuli is crucial for survival. When heat stimuli are applied to primate hairy skin, first pain sensation is mediated by type-II A-fibre nociceptors (II-AMHs). In contrast, the reported absence of first pain and II-AMH microneurographical responses when heat stimuli are applied to the hand palm has led to the notion that II-AMHs are lacking in this primate glabrous skin. The aim of this study was to assess the effect of ...

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Authors


Iannetti, GD More by this author
Zambreanu, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of Physiology
Volume:
577
Issue:
1
Pages:
235-248
Publication date:
2006-11-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:d83668d2-8b75-47b0-ade2-96e60c0fd29c
Source identifiers:
243018
Local pid:
pubs:243018
Language:
English

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