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Engineering a rugged nanoscaffold to enhance plug-and-display vaccination

Abstract:

Nanoscale organization is crucial to stimulating an immune response. Using self-assembling proteins as multimerization platforms provides a safe and immunogenic system to vaccinate against otherwise weakly immunogenic antigens. Such multimerization platforms are generally based on icosahedral viruses and have led to vaccines given to millions of people. It is unclear whether synthetic protein nanoassemblies would show similar potency. Here we take the computationally designed porous dodecahed...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acsnano.8b02805

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Worcester College
Role:
Author
ORCID:
0000-0001-8870-7147
More from this funder
Funding agency for:
Draper, S
Grant:
Senior Fellow (106917/Z/15/Z
More from this funder
Funding agency for:
Draper, S
Grant:
Senior Fellow (106917/Z/15/Z
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Nano Journal website
Volume:
12
Issue:
9
Pages:
8855–8866
Publication date:
2018-07-20
Acceptance date:
2018-07-10
DOI:
ISSN:
1936-0851
Source identifiers:
889904
Keywords:
Pubs id:
pubs:889904
UUID:
uuid:d82a8532-5eb2-482b-9cc7-5850f6420655
Local pid:
pubs:889904
Deposit date:
2018-07-20

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