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Backbone modification of retinal induces protein-like excited state dynamics in solution.

Abstract:

The drastically different reactivity of the retinal chromophore in solution compared to the protein environment is poorly understood. Here, we show that the addition of a methyl group to the C═C backbone of all-trans retinal protonated Schiff base accelerates the electronic decay in solution making it comparable to the proton pump bacteriorhodopsin. Contrary to the notion that reaction speed and efficiency are linked, we observe a concomitant 50% reduction in the isomerization yield. Our resu...

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Publication status:
Published

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Publisher copy:
10.1021/ja3007929

Authors


Bassolino, G More by this author
Schnedermann, C More by this author
Fletcher, SP More by this author
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Journal:
Journal of the American Chemical Society
Volume:
134
Issue:
20
Pages:
8318-8320
Publication date:
2012-05-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:d81f9840-e015-4d14-bb63-a933f1cc89a5
Source identifiers:
325578
Local pid:
pubs:325578

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