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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study

Abstract:
Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discovery set of 37 857 fracture c... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/bmj.k3225

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-4364-2682
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Journal website
Volume:
362
Pages:
Article: k3225
Publication date:
2018-08-29
Acceptance date:
2018-07-02
DOI:
ISSN:
0959-8138
Pubs id:
pubs:892212
URN:
uri:d81c1bc1-b15d-4e49-88cc-3f28d4e6da62
UUID:
uuid:d81c1bc1-b15d-4e49-88cc-3f28d4e6da62
Local pid:
pubs:892212

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