Journal article icon

Journal article

Combined NK₁ antagonism and serotonin reuptake inhibition: effects on emotional processing in humans.

Abstract:

BACKGROUND: Synergistic effects of NK₁ receptor antagonism combined with serotonin reuptake inhibition have been reported in preclinical models. GSK424887 is a selective competitive antagonist of the human NK₁ receptor and inhibitor of the serotonin transporter. However, its actions in human models of depression have not been assessed. METHODS: This study explored the effects of acute administration of GSK424887 compared to placebo in healthy male volunteers. The selective serotonin reuptake...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1177/0269881112472558

Authors


Expand authors...
Journal:
Journal of psychopharmacology (Oxford, England)
Volume:
27
Issue:
5
Pages:
435-443
Publication date:
2013-05-05
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
URN:
uuid:d81b14b0-53b1-47df-8f68-c6a9cfdfb1bf
Source identifiers:
384146
Local pid:
pubs:384146

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP