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Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

Abstract:

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2694

Authors


Bønnelykke, K More by this author
Matheson, MC More by this author
Granell, R More by this author
Strachan, DP More by this author
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Journal:
Nature genetics
Volume:
45
Issue:
8
Pages:
902-906
Publication date:
2013-08-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:d811297d-c19a-4c9d-99e8-eb7a73023272
Source identifiers:
410947
Local pid:
pubs:410947

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