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Journal article

Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis.

Abstract:

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is accompanied by the emergence of autoreactive T cells and a reduction in regulatory T cells. Humans and mice with SLE have reduced numbers of CD1d-restricted NK T cells, suggesting a role for these cells in the regulation of SLE. In this study, we show that CD1d deficiency exacerbates lupus nephritis induced by the hydrocarbon oil pristane. This exacerbation in disease is associated with: 1) reduced TNF-alpha and IL-4 ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.171.4.2142

Authors


Wilson, MT More by this author
Stanic, AK More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
171
Issue:
4
Pages:
2142-2153
Publication date:
2003-08-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:d80fe9e2-1417-4cde-8dab-e954665d216d
Source identifiers:
32424
Local pid:
pubs:32424

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