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Env-less endogenous retroviruses are genomic superspreaders.

Abstract:

Endogenous retroviruses (ERVs) differ from typical retroviruses in being inherited through the host germline and therefore are a unique combination of pathogen and selfish genetic element. Some ERV lineages proliferate by infecting germline cells, as do typical retroviruses, whereas others lack the env gene required for virions to enter cells and thus behave like retrotransposons. We wished to know what factors determined the relative abundance of different ERV lineages, so we analyzed ERV lo...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1200913109

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
19
Pages:
7385-7390
Publication date:
2012-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:d80de78e-d479-419b-8817-eca6a90aad42
Source identifiers:
325554
Local pid:
pubs:325554

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