Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.

Journal article

Low blood folate levels result in hyperhomocysteinemia, which has been associated with increased risk for cardiovascular disease, neural tube defects and cognitive deficits. Intake of dietary folates is the chief determinant of blood folate levels. Molecular defects in the intestinal absorption of dietary folates that precipitate low blood folate levels and hyperhomocysteinemia have not been investigated previously. Dietary folates are a mixture of polyglutamylated folates which are digested ...

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Authors: Devlin, A; Ling, E; Peerson, J; Fernando, S; Clarke, R

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 9
• Issue: 19
• Pages: 2837-2844
• Publication date: 2000-11-01
• DOI: 10.1093/hmg/9.19.2837
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Animals; Molecular Sequence Data; Cloning, Molecular; Jejunum; DNA Mutational Analysis; Alternative Splicing; Transfection; Humans; European Continental Ancestry Group; Alleles; COS Cells; Aged; Folic Acid; Isoenzymes; Intestinal Absorption; Hyperhomocysteinemia; RNA, Messenger; Middle Aged; Glutamate Carboxypeptidase II; Carboxypeptidases; Homocysteine; Antigens, Surface; Sequence Analysis, DNA; Polymorphism, Genetic