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Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.

Abstract:

Low blood folate levels result in hyperhomocysteinemia, which has been associated with increased risk for cardiovascular disease, neural tube defects and cognitive deficits. Intake of dietary folates is the chief determinant of blood folate levels. Molecular defects in the intestinal absorption of dietary folates that precipitate low blood folate levels and hyperhomocysteinemia have not been investigated previously. Dietary folates are a mixture of polyglutamylated folates which are digested ...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/9.19.2837

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Journal:
Human molecular genetics
Volume:
9
Issue:
19
Pages:
2837-2844
Publication date:
2000-11-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:d80d8db5-5dd2-4ea8-90b7-bda81c2aba12
Source identifiers:
49324
Local pid:
pubs:49324

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