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Heterogeneity of microsatellite mutations within and between loci, and implications for human demographic histories.

Abstract:

Microsatellites have been widely used to reconstruct human evolution. However, the efficient use of these markers relies on information regarding the process producing the observed variation. Here, we present a novel approach to the locus-by-locus characterization of this process. By analyzing somatic mutations in cancer patients, we estimated the distributions of mutation size for each of 20 loci. The same loci were then typed in three ethnically diverse population samples. The generalized s...

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Publication status:
Published

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Journal:
Genetics
Volume:
148
Issue:
3
Pages:
1269-1284
Publication date:
1998-03-05
EISSN:
1943-2631
ISSN:
0016-6731
URN:
uuid:d80597c1-5e42-4c57-83fd-79e03c114dc7
Source identifiers:
50050
Local pid:
pubs:50050

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