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Nuclear factories for replication, transcription and repair

Abstract:

Recent experiments suggest that the active polymerases involved in replication, transcription and the repair of damage in DNA are concentrated in large structures - 'factories' - within eukaryotic nuclei. This has forced us to reevaluate how polymerases work. The traditional view involved enzymes that tracked along templates and this was sensible if the polymerases were small relative to the templates and if they acted alone. However, immobilization of many polymerases within one factory mean...

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Publication status:
Published

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Pages:
352-361
Publication date:
1995-01-01
URN:
uuid:d8019d42-55bb-4cad-bbbb-f20e2e723bb9
Source identifiers:
23570
Local pid:
pubs:23570
ISBN:
3-00-000842-X

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