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Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells

Abstract:

The Cancer/Testis (CT) antigen family of genes are transcriptionally repressed in most human tissues but are atypically re-expressed in many malignant tumour types. Their restricted expression profile makes CT antigens ideal targets for cancer immunotherapy. As little is known about whether CT antigens may be regulated by post-translational processing, we investigated the mechanisms governing degradation of NY-ESO-1 and MAGE-C1 in selected cancer cell lines. Inhibitors of proteasome-mediated ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0083212

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
12
Pages:
e83212
Publication date:
2013-12-10
Acceptance date:
2013-10-31
DOI:
EISSN:
1932-6203
Source identifiers:
434509

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