- Abstract:
-
During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In the cardiac fields of Nkx2-5 mutants, genes controlling cardiac specification (including Bmp2) and maintenance of the progenitor state were upregulated, leading initially to progenitor overspecificat...
Expand abstract - Publisher copy:
- 10.1016/j.cell.2007.01.042
-
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- Journal:
- Cell
- Volume:
- 128
- Issue:
- 5
- Pages:
- 947-959
- Publication date:
- 2007-03-05
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- URN:
-
uuid:d7e82ec0-a2a3-400c-843a-19c9aa0f521a
- Source identifiers:
-
245644
- Local pid:
- pubs:245644
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
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