Journal article icon

Journal article

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

Abstract:

During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In the cardiac fields of Nkx2-5 mutants, genes controlling cardiac specification (including Bmp2) and maintenance of the progenitor state were upregulated, leading initially to progenitor overspecificat...

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.cell.2007.01.042

Authors


Expand authors...
Journal:
Cell
Volume:
128
Issue:
5
Pages:
947-959
Publication date:
2007-03-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:d7e82ec0-a2a3-400c-843a-19c9aa0f521a
Source identifiers:
245644
Local pid:
pubs:245644

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP