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Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial

Abstract:

Background: An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitamins.

Objective: To determine whether supplementation with B vitamins that lower levels of plasma total homocysteine can slow the rate of brain atrophy in subjects with mild cog...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0012244

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Institution:
University of Oxford
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Institution:
University of Oxford
Research group:
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain
Department:
Medical Sciences Division - Clinical Neurology
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Institution:
University of Oxford
Department:
Oxford Project to Investigate Memory and Ageing (OPTIMA)
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Institution:
University of Oxford
Department:
Oxford Project to Investigate Memory and Ageing (OPTIMA)
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Institution:
University of Oxford
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
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Charles Wolfson Charitable Trust More from this funder
Medical Research Council More from this funder
Alzheimer's Research Trust More from this funder
Henry Smith Charity More from this funder
John Coates Charitable Trust More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
5
Issue:
9
Pages:
Article: e12244
Publication date:
2010-09-05
DOI:
EISSN:
1932-6203
URN:
uuid:d7dc9420-741b-4ea4-b77b-72bf693ffff3
Local pid:
ora:5996

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