Journal article icon

Journal article

Pharmacological targeting of the HIF hydroxylases - A new field in medicine development.

Abstract:

In human cells oxygen levels are 'sensed' by a set of ferrous iron and 2-oxoglutarate dependent dioxygenases. These enzymes regulate a broad range of cellular and systemic responses to hypoxia by catalysing the post-translational hydroxylation of specific residues in the alpha subunits of hypoxia inducible factor (HIF) transcriptional complexes. The HIF hydroxylases are now the subject of pharmaceutical targeting by small molecule inhibitors that aim to activate or augment the endogenous HIF ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1016/j.mam.2016.01.001

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, CCMP
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Strategic
More from this funder
Grant:
091857/Z/10/Z; 106241/Z/14/Z
More from this funder
Grant:
C45605/A16016, C8717/A18245
Ludwig Institute for Cancer Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Molecular Aspects of Medicine Journal website
Volume:
47-48
Pages:
54-75
Publication date:
2016-01-11
DOI:
EISSN:
1872-9452
ISSN:
0098-2997
URN:
uuid:d7d1a752-965b-48b1-8a90-2290194a8ee6
Source identifiers:
597964
Local pid:
pubs:597964

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP