Collagen-induced arthritis in mice.
Collagen-induced arthritis in mice has been widely used to address questions of disease pathogenesis and to validate therapeutic targets for human rheumatoid arthritis. Arthritis is normally observed about 3 wk after immunization with autologous or heterologous type II collagen in complete Freund's adjuvant and susceptibility to the disease is strongly associated with major histocompatibility complex class II genes. The development of collagen-induced arthritis is associated with strong T- an...Expand abstract
- Methods in molecular medicine
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