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Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve.

Abstract:

Acute ischemia is a major cause of sudden arrhythmic death, further promoted by potassium current blockers. Macro-reentry around the ischemic region and early afterdepolarizations (EADs) caused by electrotonic current have been suggested as potential mechanisms in animal and isolated cell studies. However, ventricular and human-specific arrhythmia mechanisms and their modulation by repolarization reserve remain unclear. The goal of this paper is to unravel multiscale mechanisms underlying the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.pbiomolbio.2016.01.008

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Funding agency for:
Dutta, S
Grant:
Doctoral Scholarship EP/G03706X/1
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Funding agency for:
Zacur, E
Grant:
Marie Skłodowska-Curie Individual Fellowship 655020-DTI4micro-MSCA-IF-EF-ST
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Funding agency for:
Rodriguez, B
Grant:
Fellowship in Basic Biomedical Sciences 100246/Z/12/Z
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Progress in Biophysics and Molecular Biology Journal website
Publication date:
2016-02-02
Acceptance date:
2016-01-29
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
Source identifiers:
601356
Language:
English
Keywords:
Pubs id:
pubs:601356
UUID:
uuid:d7bb2310-2fb7-4179-992c-10b06d65cdec
Local pid:
pubs:601356
Deposit date:
2016-02-17

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