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Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve.

Abstract:

Acute ischemia is a major cause of sudden arrhythmic death, further promoted by potassium current blockers. Macro-reentry around the ischemic region and early afterdepolarizations (EADs) caused by electrotonic current have been suggested as potential mechanisms in animal and isolated cell studies. However, ventricular and human-specific arrhythmia mechanisms and their modulation by repolarization reserve remain unclear. The goal of this paper is to unravel multiscale mechanisms underlying the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.pbiomolbio.2016.01.008

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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Computer Science
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Institute of Biomedical Engineering
Role:
Author
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Funding agency for:
Rodriguez, B
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Progress in Biophysics and Molecular Biology Journal website
Publication date:
2016-02-02
DOI:
EISSN:
1873-1732
ISSN:
0079-6107
URN:
uuid:d7bb2310-2fb7-4179-992c-10b06d65cdec
Source identifiers:
601356
Local pid:
pubs:601356

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