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Investigating the role of the fat mass and obesity associated gene (Fto) in obesity

Abstract:

In 2007, a genome wide association study identified a SNP in intron 1 of FTO with increased BMI. Homozygous risk allele carriers are on average three kg heavier than those homozygous for the protective allele. Mouse models have been made, including a conditional knockout, which is lean when globally expressed, as well as a conditional overexpression allele, which has increased body weight when globally expressed. The results from these and other studies suggest that the FTO SNPs lead to we...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Fiona McMurray
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d7b76f58-6206-47fc-a208-7eeefac7fe27
Local pid:
ora:8287

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