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Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients.

Abstract:

BACKGROUND: Animal experimental studies suggest that the amino acid valine may decrease brain serotonin (5-HT) function by inhibiting the transport of the 5-HT precursor, L-tryptophan, across the blood barrier. The aim of the present study was to assess whether valine could decrease brain 5-HT function in healthy subjects and provoke symptomatic relapse in recently remitted depressed patients taking antidepressant drug treatment. METHOD: We studied the effect of valine (30 g) on the prolactin...

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Publication status:
Published

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Publisher copy:
10.1192/bjp.167.2.238

Authors


Journal:
The British journal of psychiatry : the journal of mental science
Volume:
167
Issue:
2
Pages:
238-242
Publication date:
1995-08-05
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
URN:
uuid:d7aa80c5-c1ec-4ac4-9815-b99d631a5605
Source identifiers:
185987
Local pid:
pubs:185987

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